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Although the three types of lightness judgments are not comparable they are frequently conflated due to the underspecified definition of lightness as perceived reflectance

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For numbers 6, 8, 11, 12, 14, 15, 16, 21, 24, the same point can be made

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forgot to mention Botox injections are also available, Botox is injected to the neck area and this will stop the red blotchy ness, the downside is you have to repeat every 6 months

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Of course somatic mutation is a known part of the development of B cell clones, and specific mutations of B cells or T cells can produce tumors rather than a disease producing autoimmunity.